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Stereoselective Synthesis of Bicyclo[6.1.0]nonene Precursors of the Bioorthogonal Reagents s-TCO and BCN

The cyclooctyne BCN and the trans-cyclooctene s-TCO are broadly used reagents for bioorthogonal chemistry. A bottleneck for the synthesis of these reagents had been a poorly selective cyclopropanation reaction with ethyl diazoacetate and catalytic Rh(2)(OAc)(4). Here, we describe that low catalyst l...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: O’Brien, Jessica G. K., Chintala, Srinivasa, Fox, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180907/
https://ncbi.nlm.nih.gov/pubmed/29171257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b02329
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