Complement receptor CD46 co-stimulates optimal human CD8(+) T cell effector function via fatty acid metabolism

The induction of human CD4(+) Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4(+) T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8(+) T cell (CTL) responses also rely on an intrinsic complement-inflammasome...

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Publicado en:Nat Commun
Main Authors: Arbore, Giuseppina, West, Erin E., Rahman, Jubayer, Le Friec, Gaelle, Niyonzima, Nathalie, Pirooznia, Mehdi, Tunc, Ilker, Pavlidis, Polychronis, Powell, Nicholas, Li, Yuesheng, Liu, Poching, Servais, Aude, Couzi, Lionel, Fremeaux-Bacchi, Veronique, Placais, Leo, Ferraro, Alastair, Walsh, Patrick R., Kavanagh, David, Afzali, Behdad, Lavender, Paul, Lachmann, Helen J., Kemper, Claudia
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180132/
https://ncbi.nlm.nih.gov/pubmed/30305631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06706-z
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