Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

Expansion and acquisition of Th1 cell effector function requires metabolic reprogramming; however, the signals instructing these adaptations remain poorly defined. Here we found that in activated human T cells, autocrine stimulation of the complement receptor CD46, and specifically its intracellular...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Kolev, Martin, Dimeloe, Sarah, Le Friec, Gaelle, Navarini, Alexander, Arbore, Giuseppina, Povoleri, Giovanni A., Fischer, Marco, Belle, Réka, Loeliger, Jordan, Develioglu, Leyla, Bantug, Glenn R., Watson, Julie, Couzi, Lionel, Afzali, Behdad, Lavender, Paul, Hess, Christoph, Kemper, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518498/
https://ncbi.nlm.nih.gov/pubmed/26084023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.05.024
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