Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats

The hypocretin/orexin (HCRT) neuropeptide system regulates feeding, arousal state, stress responses, and reward, especially under conditions of enhanced motivational relevance. In particular, HCRT neurotransmission facilitates drug-seeking behavior in circumstances that demand increased effort and/o...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Schmeichel, Brooke E., Matzeu, Alessandra, Koebel, Pascale, Vendruscolo, Leandro F., Sidhu, Harpreet, Shahryari, Roxana, Kieffer, Brigitte L., Koob, George F., Martin-Fardon, Rémi, Contet, Candice
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180106/
https://ncbi.nlm.nih.gov/pubmed/29703996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0054-4
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