Hypocretin Receptor 2 Antagonism Dose-Dependently Reduces Escalated Heroin Self-Administration in Rats

The hypocretin/orexin (HCRT) system has been associated with both positive and negative drug reinforcement, implicating HCRT receptor 1 (HCRT-R1) signaling in drug-related behaviors for all major drug classes, including opioids. However, to date there are limited studies investigating the role of HC...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Schmeichel, Brooke E, Barbier, Estelle, Misra, Kaushik K, Contet, Candice, Schlosburg, Joel E, Grigoriadis, Dimitri, Williams, John P, Karlsson, Camilla, Pitcairn, Caleb, Heilig, Markus, Koob, George F, Vendruscolo, Leandro F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367454/
https://ncbi.nlm.nih.gov/pubmed/25367502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.293
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