The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

Oncogenic transcription factors such as the leukemic fusion protein RUNX1/ETO, which drives t(8;21) acute myeloid leukemia (AML), constitute cancer-specific but highly challenging therapeutic targets. We used epigenomic profiling data for an RNAi screen to interrogate the transcriptional network mai...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Martinez-Soria, Natalia, McKenzie, Lynsey, Draper, Julia, Ptasinska, Anetta, Issa, Hasan, Potluri, Sandeep, Blair, Helen J., Pickin, Anna, Isa, Asmida, Chin, Paulynn Suyin, Tirtakusuma, Ricky, Coleman, Daniel, Nakjang, Sirintra, Assi, Salam, Forster, Victoria, Reza, Mojgan, Law, Ed, Berry, Philip, Mueller, Dorothee, Elder, Alex, Bomken, Simon N., Pal, Deepali, Allan, James M., Veal, Gareth J., Cockerill, Peter N., Wichmann, Christian, Vormoor, Josef, Lacaud, Georges, Bonifer, Constanze, Heidenreich, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179967/
https://ncbi.nlm.nih.gov/pubmed/30300583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.08.015
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