TGF-β and PI3K Signals Modulate Distinct Metabolism of Treg Subsets

Murine Foxp3(+) regulatory T cells differentiated in vitro (iTregs) in the presence of anti-inflammatory cytokine TGF-β rely predominantly upon lipid oxidation to fuel mitochondrial oxidative phosphorylation. Foxp3 expression underlies this metabolic preference as it suppresses glycolysis and drives...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Immunol
Egile Nagusiak: Priyadharshini, Bhavana, Loschi, Michael, Newton, Ryan H., Zhang, Jian-Wen, Finn, Kelsey K., Gerriets, Valerie A., Huynh, Alexandria, Rathmell, Jeffery C., Blazar, Bruce R., Turka, Laurence A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179917/
https://ncbi.nlm.nih.gov/pubmed/30209190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800311
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