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TGF-β and PI3K Signals Modulate Distinct Metabolism of Treg Subsets
Murine Foxp3(+) regulatory T cells differentiated in vitro (iTregs) in the presence of anti-inflammatory cytokine TGF-β rely predominantly upon lipid oxidation to fuel mitochondrial oxidative phosphorylation. Foxp3 expression underlies this metabolic preference as it suppresses glycolysis and drives...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6179917/ https://ncbi.nlm.nih.gov/pubmed/30209190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800311 |
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