The phosphatase PTEN-mediated control of PI-3 kinase in T(regs) cells maintains homeostasis and lineage stability

Foxp3(+) regulatory T cells (T(regs)) are required for immune homeostasis. One notable distinction between conventional T cells (T(conv)) and T(regs) is differential phosphatidylinositol 3-kinase (PI3K) activity: only T(conv) downregulate PTEN, the primary negative regulator of PI3K, upon activation...

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Udgivet i:Nat Immunol
Main Authors: Huynh, Alexandria, DuPage, Michel, Priyadharshini, Bhavana, Sage, Peter T., Quiros, Jason, Borges, Christopher M., Townamchai, Natavudh, Gerriets, Valerie A., Rathmell, Jeffrey C., Sharpe, Arlene H., Bluestone, Jeffrey A., Turka, Laurence A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297515/
https://ncbi.nlm.nih.gov/pubmed/25559257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3077
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