Glucocorticoid Receptor Mutations and Hypersensitivity to Endogenous and Exogenous Glucocorticoids

BACKGROUND: The glucocorticoid receptor (GR) consists of two alternatively spliced isoforms: GRα, which activates gene transcription, and GRβ, a dominant-negative receptor. Theoretically, inactivating variants of GRβ could result in glucocorticoid hypersensitivity. DESIGN: A 46-year-old woman presen...

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Bibliographic Details
Published in:J Clin Endocrinol Metab
Main Authors: Santen, Richard J, Jewell, Christine M, Yue, Wei, Heitjan, Daniel F, Raff, Hershel, Katen, Kevin S, Cidlowski, John A
Format: Artigo
Language:Inglês
Published: Endocrine Society 2018
Subjects:
Clinical Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179182/
https://ncbi.nlm.nih.gov/pubmed/30020469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2018-00352
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