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Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor

Alternative splicing of the human glucocorticoid receptor gene generates two isoforms, hGRα and hGRβ. hGRβ functions as a dominant-negative regulator of hGRα activity and but also has inherent transcriptional activity, collectively altering glucocorticoid sensitivity. Single-nucleotide polymorphisms...

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Detalhes bibliográficos
Publicado no:Lab Invest
Main Authors: Whirledge, Shannon D, Jewell, Christine M, Barber, Lisa M, Xu, Xiaojiang, Katen, Kevin S, Garantziotis, Stavros, Cidlowski, John A
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759773/
https://ncbi.nlm.nih.gov/pubmed/28759007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2017.76
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