Complex Human Glucocorticoid Receptor dim Mutations Define Glucocorticoid Induced Apoptotic Resistance in Bone Cells

A mutation in the D-loop of the second zinc finger of the DNA-binding domain of the human glucocorticoid receptor (hGR), A458T (GR(dim)), has been suggested to be essential for dimerization and DNA binding of the GR, and genetically altered GR(dim) mice survive, whereas murine GR knockout mice die....

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Detaylı Bibliyografya
Asıl Yazarlar: Jewell, Christine M., Scoltock, Alyson B., Hamel, Brant L., Yudt, Matthew R., Cidlowski, John A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2012
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275167/
https://ncbi.nlm.nih.gov/pubmed/22174376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1116
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