Complex Human Glucocorticoid Receptor dim Mutations Define Glucocorticoid Induced Apoptotic Resistance in Bone Cells

A mutation in the D-loop of the second zinc finger of the DNA-binding domain of the human glucocorticoid receptor (hGR), A458T (GR(dim)), has been suggested to be essential for dimerization and DNA binding of the GR, and genetically altered GR(dim) mice survive, whereas murine GR knockout mice die....

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Detalhes bibliográficos
Main Authors: Jewell, Christine M., Scoltock, Alyson B., Hamel, Brant L., Yudt, Matthew R., Cidlowski, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275167/
https://ncbi.nlm.nih.gov/pubmed/22174376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1116
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