Complex Human Glucocorticoid Receptor dim Mutations Define Glucocorticoid Induced Apoptotic Resistance in Bone Cells

A mutation in the D-loop of the second zinc finger of the DNA-binding domain of the human glucocorticoid receptor (hGR), A458T (GR(dim)), has been suggested to be essential for dimerization and DNA binding of the GR, and genetically altered GR(dim) mice survive, whereas murine GR knockout mice die....

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Détails bibliographiques
Auteurs principaux: Jewell, Christine M., Scoltock, Alyson B., Hamel, Brant L., Yudt, Matthew R., Cidlowski, John A.
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2012
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275167/
https://ncbi.nlm.nih.gov/pubmed/22174376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1116
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