Interferon-α Triggers Autoimmune Thyroid Diseases via Lysosomal-Dependent Degradation of Thyroglobulin

CONTEXT: Autoimmune thyroid diseases (AITDs) arise from complex interactions among genetic, epigenetic, and environmental factors. Thyroglobulin (TG) is a major susceptibility gene for both Graves disease and Hashimoto thyroiditis. Interferon-α (IFNα), a cytokine secreted during viral infections, ha...

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Detalles Bibliográficos
Publicado en:J Clin Endocrinol Metab
Main Authors: Faustino, Larissa C, Lombardi, Angela, Madrigal-Matute, Julio, Owen, Randall P, Libutti, Steven K, Tomer, Yaron
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2018
Assuntos:
Clinical Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179164/
https://ncbi.nlm.nih.gov/pubmed/30113675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2018-00541
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