Genetic–epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity

Graves disease (GD) is an autoimmune condition caused by interacting genetic and environmental factors. Genetic studies have mapped several single-nucleotide polymorphisms (SNPs) that are strongly associated with GD, but the mechanisms by which they trigger disease are unknown. We hypothesized that...

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Autors principals: Stefan, Mihaela, Wei, Chengguo, Lombardi, Angela, Li, Cheuk Wun, Concepcion, Erlinda S., Inabnet, William B., Owen, Randall, Zhang, Weijia, Tomer, Yaron
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151767/
https://ncbi.nlm.nih.gov/pubmed/25122677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408821111
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