Genetic–epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity

Graves disease (GD) is an autoimmune condition caused by interacting genetic and environmental factors. Genetic studies have mapped several single-nucleotide polymorphisms (SNPs) that are strongly associated with GD, but the mechanisms by which they trigger disease are unknown. We hypothesized that...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Stefan, Mihaela, Wei, Chengguo, Lombardi, Angela, Li, Cheuk Wun, Concepcion, Erlinda S., Inabnet, William B., Owen, Randall, Zhang, Weijia, Tomer, Yaron
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2014
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151767/
https://ncbi.nlm.nih.gov/pubmed/25122677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408821111
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