Genetic–epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity

Graves disease (GD) is an autoimmune condition caused by interacting genetic and environmental factors. Genetic studies have mapped several single-nucleotide polymorphisms (SNPs) that are strongly associated with GD, but the mechanisms by which they trigger disease are unknown. We hypothesized that...

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Hlavní autoři: Stefan, Mihaela, Wei, Chengguo, Lombardi, Angela, Li, Cheuk Wun, Concepcion, Erlinda S., Inabnet, William B., Owen, Randall, Zhang, Weijia, Tomer, Yaron
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151767/
https://ncbi.nlm.nih.gov/pubmed/25122677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408821111
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