Cepharanthine blocks TSH receptor peptide presentation by HLA-DR3: Therapeutic implications to Graves’ disease

We have previously identified a signature HLA-DR3 pocket variant, designated HLA-DRβ1-Arg74 that confers a high risk for Graves’ Disease (GD). In view of the key role of HLA-DRβ1-Arg74 in triggering GD we hypothesized that thyroid-stimulating hormone receptor (TSHR) peptides that bind to the HLA-DRβ...

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Bibliografiska uppgifter
I publikationen:J Autoimmun
Huvudupphovsmän: Li, Cheuk Wun, Osman, Roman, Menconi, Francesca, Concepcion, Erlinda, Tomer, Yaron
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819272/
https://ncbi.nlm.nih.gov/pubmed/31980336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2020.102402
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