Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis

We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases (AITD). We also identified 5 thyroglobulin (Tg) peptides that bound to DRβ1-Arg74. We hypothesized that b...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Cheuk Wun, Menconi, Francesca, Osman, Roman, Mezei, Mihaly, Jacobson, Eric M., Concepcion, Erlinda, David, Chella S., Kastrinsky, David B., Ohlmeyer, Michael, Tomer, Yaron
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759184/
https://ncbi.nlm.nih.gov/pubmed/26703475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.694687
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