Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis

We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases (AITD). We also identified 5 thyroglobulin (Tg) peptides that bound to DRβ1-Arg74. We hypothesized that b...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Li, Cheuk Wun, Menconi, Francesca, Osman, Roman, Mezei, Mihaly, Jacobson, Eric M., Concepcion, Erlinda, David, Chella S., Kastrinsky, David B., Ohlmeyer, Michael, Tomer, Yaron
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2016
Aiheet:
Metabolism
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759184/
https://ncbi.nlm.nih.gov/pubmed/26703475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.694687
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