Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis

There is strong genetic association between type 1A diabetes (T1D) and autoimmune thyroid disease (AITD). T1D and AITD frequently occur together in the same individual, a condition classified as a variant of the autoimmune polyglandular syndrome type 3 (APS3). Because T1D and AITD are individually s...

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Bibliographic Details
Main Authors: Menconi, Francesca, Osman, Roman, Monti, Maria C., Greenberg, David A., Concepcion, Erlinda S., Tomer, Yaron
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947869/
https://ncbi.nlm.nih.gov/pubmed/20837527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009511107
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