Novel Variant of Thyroglobulin Promoter Triggers Thyroid Autoimmunity through an Epigenetic Interferon α-modulated Mechanism

Autoimmune thyroid diseases (AITD) arise from complex interactions between genetic, epigenetic, and environmental factors. Whole genome linkage scans and association studies have established thyroglobulin (TG) as a major AITD susceptibility gene. However, the causative TG variants and the pathogenic...

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Detalhes bibliográficos
Main Authors: Stefan, Mihaela, Jacobson, Eric M., Huber, Amanda K., Greenberg, David A., Li, Cheuk Wun, Skrabanek, Luce, Conception, Erlinda, Fadlalla, Mohammed, Ho, Kenneth, Tomer, Yaron
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173071/
https://ncbi.nlm.nih.gov/pubmed/21757724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.247510
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