Mechanical cues control mutant p53 stability through a Mevalonate/RhoA axis

Tumour-associated p53 missense mutants act as driver oncogenes impacting cancer progression, metastatic potential and drug resistance (Gain-of-Function, GOF)1. Mutant p53 protein stabilization is a prerequisite for GOF manifestation, however it does not represent an intrinsic property of p53 mutants...

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Udgivet i:Nat Cell Biol
Main Authors: Ingallina, Eleonora, Sorrentino, Giovanni, Bertolio, Rebecca, Lisek, Kamil, Zannini, Alessandro, Azzolin, Luca, Severino, Luisa Ulloa, Scaini, Denis, Mano, Miguel, Mantovani, Fiamma, Rosato, Antonio, Bicciato, Silvio, Piccolo, Stefano, Del Sal, Giannino
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179142/
https://ncbi.nlm.nih.gov/pubmed/29255172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-017-0009-8
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