KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice

KDM6B is an epigenetic regulator that mediates transcriptional activation during differentiation, including in bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs). Overexpression of KDM6B has been reported in BM HSPCs of patients with myelodysplastic syndromes (MDS) and chronic myelomon...

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發表在:Blood Adv
Main Authors: Wei, Yue, Zheng, Hong, Bao, Naran, Jiang, Shan, Bueso-Ramos, Carlos E., Khoury, Joseph, Class, Caleb, Lu, Yue, Lin, Kevin, Yang, Hui, Ganan-Gomez, Irene, Starczynowski, Daniel T., Do, Kim-Anh, Colla, Simona, Garcia-Manero, Guillermo
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2018
主題:
Myeloid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177657/
https://ncbi.nlm.nih.gov/pubmed/30275007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024166
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