KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice

KDM6B is an epigenetic regulator that mediates transcriptional activation during differentiation, including in bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs). Overexpression of KDM6B has been reported in BM HSPCs of patients with myelodysplastic syndromes (MDS) and chronic myelomon...

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Bibliografiset tiedot
Julkaisussa:Blood Adv
Päätekijät: Wei, Yue, Zheng, Hong, Bao, Naran, Jiang, Shan, Bueso-Ramos, Carlos E., Khoury, Joseph, Class, Caleb, Lu, Yue, Lin, Kevin, Yang, Hui, Ganan-Gomez, Irene, Starczynowski, Daniel T., Do, Kim-Anh, Colla, Simona, Garcia-Manero, Guillermo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2018
Aiheet:
Myeloid Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177657/
https://ncbi.nlm.nih.gov/pubmed/30275007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024166
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