Copy number alterations detected as clonal hematopoiesis of indeterminate potential

Recent studies have revealed that clonal hematopoiesis of indeterminate potential (CHIP) is an important risk factor for therapy-related myeloid neoplasms (t-MNs). CHIP is currently defined as a clonal hematopoietic population carrying somatic point mutations in 1 of the leukemia-associated genes. P...

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Pubblicato in:Blood Adv
Autori principali: Takahashi, Koichi, Wang, Feng, Kantarjian, Hagop, Song, Xingzhi, Patel, Keyur, Neelapu, Sattva, Gumbs, Curtis, Little, Latasha, Tippen, Samantha, Thornton, Rebecca, DiNardo, Courtney D., Ravandi, Farhad, Bueso-Ramos, Carlos, Zhang, Jianhua, Wu, Xifeng, Garcia-Manero, Guillermo, Futreal, P. Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728325/
https://ncbi.nlm.nih.gov/pubmed/29296745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007922
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