Copper regulates the interactions of antimicrobial piscidin peptides from fish mast cells with formyl peptide receptors and heparin

Phagocytic cells in fish secrete antimicrobial peptides (AMPs) such as piscidins, glycosaminoglycans such as heparin, and copper ions as first-line immune defenses. Recently, we established that Cu(2+) coordination by piscidins 1 (P1) and 3 (P3) enhances their antibacterial activity against membrane...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kim, So Young, Zhang, Fuming, Gong, Wanghua, Chen, Keqiang, Xia, Kai, Liu, Fei, Gross, Richard, Wang, Ji Ming, Linhardt, Robert J., Cotten, Myriam L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177607/
https://ncbi.nlm.nih.gov/pubmed/30158246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001904
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