High-Resolution Structures and Orientations of Antimicrobial Peptides Piscidin 1 and Piscidin 3 in Fluid Bilayers Reveal Tilting, Kinking, and Bilayer Immersion

[Image: see text] While antimicrobial peptides (AMPs) have been widely investigated as potential therapeutics, high-resolution structures obtained under biologically relevant conditions are lacking. Here, the high-resolution structures of the homologous 22-residue long AMPs piscidin 1 (p1) and pisci...

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Auteurs principaux: Perrin, B. Scott, Tian, Ye, Fu, Riqiang, Grant, Christopher V., Chekmenev, Eduard Y., Wieczorek, William E., Dao, Alexander E., Hayden, Robert M., Burzynski, Caitlin M., Venable, Richard M., Sharma, Mukesh, Opella, Stanley J., Pastor, Richard W., Cotten, Myriam L.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985945/
https://ncbi.nlm.nih.gov/pubmed/24410116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja411119m
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