HGF-induced formation of the MET–AXL–ELMO2–DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion

The MET proto-oncogene–encoded receptor tyrosine kinase (MET) and AXL receptor tyrosine kinase (AXL) are independently operating receptor tyrosine kinases (RTKs) that are functionally associated with aggressive and invasive cancer cell growth. However, how MET and AXL regulate the migratory properti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Wenjing, Xiong, Xiahui, Abdalla, Amro, Alejo, Salvador, Zhu, Linyu, Lu, Fei, Sun, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177597/
https://ncbi.nlm.nih.gov/pubmed/30108175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003063
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