The Bipartite Rac1 Guanine Nucleotide Exchange Factor Engulfment and Cell Motility 1/Dedicator of Cytokinesis 180 (Elmo1/Dock180) Protects Endothelial Cells from Apoptosis in Blood Vessel Development

Engulfment and cell motility 1/dedicator of cytokinesis 180 (Elmo1/Dock180) is a bipartite guanine nucleotide exchange factor for the monomeric GTPase Ras-related C3 botulinum toxin substrate 1 (Rac1). Elmo1/Dock180 regulates Rac1 activity in a specific spatiotemporal manner in endothelial cells (EC...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Schäker, Kathrin, Bartsch, Susanne, Patry, Christian, Stoll, Sandra J., Hillebrands, Jan-Luuk, Wieland, Thomas, Kroll, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358276/
https://ncbi.nlm.nih.gov/pubmed/25586182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.633701
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