A non-canonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis

Rheumatoid arthritis is characterized by progressive joint inflammation and affects ~1% of the human population. We noted single nucleotide polymorphisms (SNPs) in the apoptotic cell engulfment genes ELMO1, DOCK2, and RAC1 linked to rheumatoid arthritis. As ELMO1 promotes cytoskeletal reorganization...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Arandjelovic, Sanja, Perry, Justin S.A., Lucas, Christopher D., Penberthy, Kristen K., Kim, Tae-Hyoun, Zhou, Ming, Rosen, Dorian A, Chuang, Tzu-Ying, Bettina, Alexandra M., Shankman, Laura S., Cohen, Amanda H., Gaultier, Alban, Conrads, Thomas P., Kim, Minsoo, Elliott, Michael R., Ravichandran, Kodi S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402828/
https://ncbi.nlm.nih.gov/pubmed/30643265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0293-x
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