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Molecular mechanism of poliovirus Sabin vaccine strain attenuation

Recruitment of poliovirus (PV) RNA to the human ribosome requires the coordinated interaction of the viral internal ribosome entry site (IRES) and several host cellular initiation factors and IRES trans-acting factors (ITAFs). Attenuated PV Sabin strains contain point mutations in the PV IRES domain...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Avanzino, Brian C., Jue, Helen, Miller, Clare M., Cheung, Emily, Fuchs, Gabriele, Fraser, Christopher S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177584/
https://ncbi.nlm.nih.gov/pubmed/30126841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004913
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