Molecular mechanism of poliovirus Sabin vaccine strain attenuation

Recruitment of poliovirus (PV) RNA to the human ribosome requires the coordinated interaction of the viral internal ribosome entry site (IRES) and several host cellular initiation factors and IRES trans-acting factors (ITAFs). Attenuated PV Sabin strains contain point mutations in the PV IRES domain...

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Vydáno v:J Biol Chem
Hlavní autoři: Avanzino, Brian C., Jue, Helen, Miller, Clare M., Cheung, Emily, Fuchs, Gabriele, Fraser, Christopher S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177584/
https://ncbi.nlm.nih.gov/pubmed/30126841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004913
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