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Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures
The type 2 K(+)/Cl(−) cotransporter (KCC2) allows neurons to maintain low intracellular levels of Cl(−), a prerequisite for efficient synaptic inhibition. Reductions in KCC2 activity are evident in epilepsy; however, whether these deficits directly contribute to the underlying pathophysiology remain...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176565/ https://ncbi.nlm.nih.gov/pubmed/30224498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810134115 |
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