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Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential

KCC2 comprises the major Cl(−) extruding mechanism in most adult neurons. Hyperpolarizing GABAergic transmission depends on KCC2 function. We recently demonstrated that glutamate reduces KCC2 function by a phosphorylation-dependent mechanism that leads to excitatory GABA responses. Here we investiga...

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Detalhes bibliográficos
Main Authors: Deeb, Tarek Z, Lee, Henry HC, Walker, Josh A, Davies, Paul A, Moss, Stephen J
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265795/
https://ncbi.nlm.nih.gov/pubmed/22082832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.5.6.17952
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