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NMDA receptor activity downregulates KCC2 resulting in depolarizing GABA(A) receptor mediated currents
KCC2 is a neuron-specific K(+)-Cl(−) cotransporter that maintains a low intracellular Cl(−) concentration essential for hyperpolarizing inhibition mediated by GABA(A) receptors. Deficits in KCC2 activity occur in disease states associated with pathophysiological glutamate release. However, the mecha...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102766/ https://ncbi.nlm.nih.gov/pubmed/21532577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2806 |
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