DNMTs inhibitor SGI-1027 induces apoptosis in Huh7 human hepatocellular carcinoma cells

SGI-1027, a novel class of relatively stable, highly lipophilic quinoline-based small-molecule inhibitors of DNA methyltransferase enzymes (DNMTs), is able to inhibit DNMTs activity, and reactivate tumor suppressor genes. However, the potential anticancer mechanisms of SGI-1027 on human hepatocellul...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncol Lett
Auteurs principaux: Sun, Ning, Zhang, Jialin, Zhang, Chengshuo, Zhao, Bochao, Jiao, Ao
Format: Artigo
Langue:Inglês
Publié: D.A. Spandidos 2018
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176375/
https://ncbi.nlm.nih.gov/pubmed/30344731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2018.9390
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