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Molecular Modeling Studies of the Novel Inhibitors of DNA Methyltransferases SGI-1027 and CBC12: Implications for the Mechanism of Inhibition of DNMTs

DNA methylation is an epigenetic modification that regulates gene expression by DNA methyltransferases (DNMTs). Inhibition of DNMTs is a promising approach for cancer therapy. Recently, novel classes of the quinolone-based compound, SGI-1027, and RG108-procainamide conjugates, CBC12, have been ident...

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Detaylı Bibliyografya
Asıl Yazarlar: Yoo, Jakyung, Choi, Sun, Medina-Franco, José L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636198/
https://ncbi.nlm.nih.gov/pubmed/23637988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062152
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