Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic...

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Gepubliceerd in:Commun Biol
Hoofdauteurs: de Jong, Simone, Diniz, Mateus Jose Abdalla, Saloma, Andiara, Gadelha, Ary, Santoro, Marcos L., Ota, Vanessa K., Noto, Cristiano, Curtis, Charles, Newhouse, Stephen J., Patel, Hamel, Hall, Lynsey S., O`Reilly, Paul F., Belangero, Sintia I., Bressan, Rodrigo A., Breen, Gerome
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175827/
https://ncbi.nlm.nih.gov/pubmed/30320231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0155-y
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