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Genetic variants of GCH1 associate with chronic and acute crisis pain in African Americans with sickle cell disease

The multidimensional nature of pain in sickle cell disease (SCD) has rendered its therapeutic management extremely challenging. In this study, we explored the role of five single nucleotide polymorphisms (SNPs) of candidate gene GCH1 in SCD pain. Composite pain index (CPI) scores and acute care util...

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Bibliografiske detaljer
Udgivet i:Exp Hematol
Main Authors: Sadhu, Nilanjana, Jhun, Ellie H., Yao, Yingwei, He, Ying, Molokie, Robert E., Wilkie, Diana J., Wang, Zaijie Jim
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175655/
https://ncbi.nlm.nih.gov/pubmed/30031848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.07.004
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