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Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop

Monoclonal antibodies (mAbs) with pan-ebolavirus cross-reactivity are highly desirable, but development of such mAbs is limited by a lack of a molecular understanding of cross-reactive epitopes. The anti body ADI-15878 was previously identified from a human survivor of Ebola virus Makona variant (EB...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Murin, Charles D., Bruhn, Jessica F., Bornholdt, Zachary A., Copps, Jeffrey, Stanfield, Robyn, Ward, Andrew B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174886/
https://ncbi.nlm.nih.gov/pubmed/30184505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.009
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