Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma

Cancer immunotherapy has made unprecedented breakthrough in the fields of chimeric antigen receptor-redirected T (CAR T) cell therapy and immune modulation. Combination of CAR modification and the disruption of endogenous inhibitory immune checkpoints on T cells represent a promising immunotherapeut...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Guo, Xingliang, Jiang, Hua, Shi, Bizhi, Zhou, Min, Zhang, Honghong, Shi, Zhimin, Du, Guoxiu, Luo, Hong, Wu, Xiuqi, Wang, Yi, Sun, Ruixin, Li, Zonghai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174208/
https://ncbi.nlm.nih.gov/pubmed/30327605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01118
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