Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice

A hostile tumor microenvironment is one of the major obstacles for the efficacy of chimeric antigen receptor modified T (CAR-T) cells, and combination treatment might be a potential way to overcome this obstacle. Poly(ADP-ribose) polymerase inhibitor (PARPi) has demonstrated tremendous potential in...

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Publicado en:Mol Ther
Autores principales: Sun, Ruixin, Luo, Hong, Su, Jingwen, Di, Shengmeng, Zhou, Min, Shi, Bizhi, Sun, Yansha, Du, Guoxiu, Zhang, Honghong, Jiang, Hua, Li, Zonghai
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2021
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791086/
https://ncbi.nlm.nih.gov/pubmed/33010818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.09.034
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