Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells

Chimeric antigen receptor modified T cells (CAR-T) therapy is an emerging immunotherapy against malignancies. However, only limited success was obtained in solid tumors. Polyinosinic-polycytidylic acid (poly I:C), ligand of TLR3, mediates innate immune and adaptive immune and shows broad antitumor e...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Di, Shengmeng, Zhou, Min, Pan, Zeyan, Sun, Ruixin, Chen, Muhua, Jiang, Hua, Shi, Bizhi, Luo, Hong, Li, Zonghai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481273/
https://ncbi.nlm.nih.gov/pubmed/31058074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00241
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