Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor SGI-110 in Hepatocellular Carcinoma

There is an urgent need for developing more effective therapies for hepatocellular carcinoma (HCC) because of its aggressiveness. Guadecitabine (SGI-110) is a second-generation DNA methyltransferase inhibitor (DNMTi) currently in clinical trials for HCC and shows greater stability and performance ov...

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Publicat a:Hepatology
Autors principals: Liu, Minmin, Zhang, Lian, Li, Hongtao, Hinoue, Toshinori, Zhou, Wanding, Ohtani, Hitoshi, El-Khoueiry, Anthony, Daniels, John, O’Connell, Casey, Dorff, Tanya B., Lu, Qianjin, Weisenberger, Daniel J., Liang, Gangning
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173644/
https://ncbi.nlm.nih.gov/pubmed/29774579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30091
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