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A bacterial chromosome structuring protein binds overtwisted DNA to stimulate type II topoisomerases and enable DNA replication

When DNA is unwound during replication, it becomes overtwisted and forms positive supercoils in front of the translocating DNA polymerase. Unless removed or dissipated, this superhelical tension can impede replication elongation. Topoisomerases, including gyrase and topoisomerase IV in bacteria, are...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Guo, Monica S., Haakonsen, Diane L., Zeng, Wenjie, Schumacher, Maria A., Laub, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173638/
https://ncbi.nlm.nih.gov/pubmed/30220456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.029
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