Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type immune response to helminth parasites. However, its role in the later effector phase of clearing chronic infection remains unclear. The helminth Heligmosomoides polygyrus establishes long-te...

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Pubblicato in:eLife
Autori principali: Smith, Katherine A, Löser, Stephan, Varyani, Fumi, Harcus, Yvonne, McSorley, Henry J, McKenzie, Andrew NJ, Maizels, Rick M
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Immunology and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173579/
https://ncbi.nlm.nih.gov/pubmed/30238872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38269
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