Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type immune response to helminth parasites. However, its role in the later effector phase of clearing chronic infection remains unclear. The helminth Heligmosomoides polygyrus establishes long-te...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Smith, Katherine A, Löser, Stephan, Varyani, Fumi, Harcus, Yvonne, McSorley, Henry J, McKenzie, Andrew NJ, Maizels, Rick M
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2018
Sujets:
Immunology and Inflammation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173579/
https://ncbi.nlm.nih.gov/pubmed/30238872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38269
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