Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type immune response to helminth parasites. However, its role in the later effector phase of clearing chronic infection remains unclear. The helminth Heligmosomoides polygyrus establishes long-te...

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Bibliographic Details
Published in:eLife
Main Authors: Smith, Katherine A, Löser, Stephan, Varyani, Fumi, Harcus, Yvonne, McSorley, Henry J, McKenzie, Andrew NJ, Maizels, Rick M
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Immunology and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173579/
https://ncbi.nlm.nih.gov/pubmed/30238872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38269
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