Berenil Binds Tightly to Parallel and Mixed Parallel/Antiparallel G-Quadruplex Motifs with Varied Thermodynamic Signatures

[Image: see text] Diminazene, DMZ, (or berenil) has been reported as a tight binder of G-quadruplexes. G-Quadruplex structures are often located in the promotor regions of oncogenes and may play a regulatory role in gene expression based on the stability of the folding topology. In this study, attem...

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Udgivet i:ACS Omega
Main Authors: Mikek, Clinton G., West, Savannah J., Gwin, J. Cole, Dayal, Neetu, Sintim, Herman O., Lewis, Edwin A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173502/
https://ncbi.nlm.nih.gov/pubmed/30320266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01621
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