Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

Dysregulation of the complement system is implicated in neurodegeneration, including human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by local complement upregulation and activation, but whether targeting this early innate immune response could have therapeutic benef...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Bosco, Alejandra, Anderson, Sarah R., Breen, Kevin T., Romero, Cesar O., Steele, Michael R., Chiodo, Vince A., Boye, Sanford L., Hauswirth, William W., Tomlinson, Stephen, Vetter, Monica L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171099/
https://ncbi.nlm.nih.gov/pubmed/30217731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.08.017
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