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Complex I Subunit Gene Therapy With NDUFA6 Ameliorates Neurodegeneration in EAE
PURPOSE. To address the permanent disability induced by mitochondrial dysfunction in experimental autoimmune encephalomyelitis (EAE). METHODS. Mice sensitized for EAE were rescued by intravitreal injection of adeno-associated viral vector serotype 2 with the complex I subunit gene scAAV-NDUFA6Flag....
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| Publicado no: | Invest Ophthalmol Vis Sci |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Association for Research in Vision and Ophthalmology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4329968/ https://ncbi.nlm.nih.gov/pubmed/25613946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-15950 |
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