cAMP attenuates TGF-β’s profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4

Osteoarthritis (OA) is characterized by synovitis and synovial fibrosis. Synoviocytes are fibroblast-like resident cells of the synovium that are activated by transforming growth factor (TGF)-β to proliferate, migrate, and produce extracellular matrix. Synoviocytes secrete hyaluronan (HA) and proteo...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Qadri, Marwa M., Jay, Gregory D., Ostrom, Rennolds S., Zhang, Ling X., Elsaid, Khaled A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171038/
https://ncbi.nlm.nih.gov/pubmed/29898378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00041.2018
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky