cAMP attenuates TGF-β’s profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4

Osteoarthritis (OA) is characterized by synovitis and synovial fibrosis. Synoviocytes are fibroblast-like resident cells of the synovium that are activated by transforming growth factor (TGF)-β to proliferate, migrate, and produce extracellular matrix. Synoviocytes secrete hyaluronan (HA) and proteo...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Qadri, Marwa M., Jay, Gregory D., Ostrom, Rennolds S., Zhang, Ling X., Elsaid, Khaled A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171038/
https://ncbi.nlm.nih.gov/pubmed/29898378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00041.2018
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