The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

BACKGROUND: Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for CD44 receptor. rhPRG4-CD44 interaction inhibits cytokine-induced rheumatoid arth...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Alquraini, Ali, Jamal, Maha, Zhang, Ling, Schmidt, Tannin, Jay, Gregory D., Elsaid, Khaled A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423025/
https://ncbi.nlm.nih.gov/pubmed/28482921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1301-5
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