The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid

BACKGROUND: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. PRG4 has a homeostatic multifaceted role in the joint. PRG4 intra-articular treatment retards progression of cartilage degeneration in pre-clinical posttraumatic...

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Foilsithe in:Arthritis Res Ther
Main Authors: Alquraini, Ali, Garguilo, Steven, D’Souza, Gerard, Zhang, Ling X., Schmidt, Tannin A., Jay, Gregory D., Elsaid, Khaled A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672561/
https://ncbi.nlm.nih.gov/pubmed/26643105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0877-x
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