BAP1 links metabolic regulation of ferroptosis to tumor suppression

The roles and regulatory mechanisms of ferroptosis, a non-apoptotic form of cell death, in cancer remain unclear. The tumor suppressor BRCA1-associated protein 1 (BAP1) encodes a nuclear de-ubiquitinating (DUB) enzyme to reduce histone 2A ubiquitination (H2Aub) on chromatin. Here integrated transcri...

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Publicado no:Nat Cell Biol
Main Authors: Zhang, Yilei, Shi, Jiejun, Liu, Xiaoguang, Feng, Li, Gong, Zihua, Koppula, Pranavi, Sirohi, Kapil, Li, Xu, Wei, Yongkun, Lee, Hyemin, Zhuang, Li, Chen, Gang, Xiao, Zhen-Dong, Hung, Mien-Chie, Chen, Junjie, Huang, Peng, Li, Wei, Gan, Boyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170713/
https://ncbi.nlm.nih.gov/pubmed/30202049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0178-0
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